ABSTRACT
Objectives To evaluates carbon dioxide (CO
ABSTRACT
Tonsillectomy is one of the most commonly performed surgical procedures in otolaryngology. There are several operative methods currently in use, but the superiority of one over another has not been clearly demonstrated. Objective: To compare intraoperative efficiency and postoperative recovery between dissection and coblation tonsillectomy. Patients and Methods: This prospective clinical study was conducted at Rizgary teaching hospital/ Erbil, and Baghdad private hospitals from 29th November 2011 to 17th July 2012. The study included 100 patients who underwent tonsillectomy, half of them by coblation and the other half by cold dissection technique. Both techniques performed under general anaesthesia. Each tonsillectomy technique was assessed intraoperatively for amount of blood loss, and duration of operation. Postoperatively they were assessed for pain, hemorrhage, and day of return to normal activity and normal diet. Results: Duration of operations was significantly shorter for the coblation group versus the dissection group [17.7 min vs 22.3 min, P= 0.000]. Intraoperative blood loss was statically lower for the coblation versus the dissection group [45.3 ml vs. 74.7 ml, P= 0.003]. There was statically significant differences in daily pain scores and return to normal diet and activity between two groups [mean 5.7 day for coblation vs. 7.32 day for the dissection, P= 0.001]. And only two patients [4%] in coblation group developed secondary bleeding.Conclusion: Coblation tonsillectomy offers better operative speed, intraoperative hemostasis, less postoperative pain scores and faster recoveries than dissection tonsillectomy especially in pediatric age group
ABSTRACT
Boerhaavia diffusa, Linn (Fam: Nyctagenaceae), is widely used for the treatment of Jaundice in various parts of India. In the present study, cancer chemopreventive property of B. diffusa was evaluated on 7,12-dimethyl benz(a)anthracene (DMBA) induced skin papillomagenesis in male Swiss albino mice (6-7 weeks old). A single topical application of 7,12-dimethyl benz(a)anthracene (50 microg/50 microl of acetone), followed 2 weeks later by repeated application of croton oil (1% in acetone three times a week) and continued till the end of the experiment exhibited 100% tumor incidence. In contrast, mice treated topically on the shaven backs with the Boerhaavia diffusa extract at either the peri-initiational phase (i.e. 7 days before and 7 days after the application of DMBA; Group II), post initiational phase (i.e. from the day of start of croton oil treatment and continued till the end of the experiment; Group III) or continuously at the peri- and post-initiational stages (i.e. 7 days prior to DMBA application and continued till the end of the experiment; Group IV), a significant reduction in the values of tumor incidence (Group II - 65%; Group III - 30%; Group IV - 25%), average number of tumors per tumor bearing mouse (Group II - 2.8; Group III - 0.75; Group IV - 0.35) and papillomas per papilloma bearing mouse (Group II - 3.1; Group III - 2.5; Group IV - 1.2) were observed.
Subject(s)
9,10-Dimethyl-1,2-benzanthracene/toxicity , Animals , Male , Mice , Nyctaginaceae , Papilloma/chemically induced , Phytotherapy/methods , Plant Extracts/isolation & purification , Plant Leaves , Plant Stems , Skin Neoplasms/chemically inducedABSTRACT
The modulatory effects of a hydro-alcoholic extract of drumsticks of Moringa oliefera Lam at doses of 125 mg/kg bodyweight and 250 mg/ kg body weight for 7 and 14 days, respectively, were investigated with reference to drug metabolising Phase I (Cytochrome b(5) and Cytochrome p(450) ) and Phase II (Glutathione-S- transferase) enzymes, anti-oxidant enzymes, glutathione content and lipid peroxidation in the liver of 6-8 week old female Swiss albino mice. Further, the chemopreventive efficacy of the extract was evaluated in a two stage model of 7,12 - dimethylbenz(a)anthracene induced skin papillomagenesis. Significant increase (p<0.05 to p<0.01) in the activities of hepatic cytochrome b(5), cytochrome p(450), catalase, glutathione peroxidase ( GPx ), glutathione reductase (GR), acid soluble sulfhydryl content (-SH ) and a significant decrease ( p<0.01 ) in the hepatic MDA level were observed at both dose levels of treatment when compared with the control values. Glutathione-S- transferase ( GST )activity was found to be significantly increased (p<0.01 ) only at the higher dose level. Butylated hydroxyanisol (BHA ) fed at a dose of 0.75% in the diet for 7 and 14 days (positive control ) caused a significant increase (p<0.05 to p<0.01) in the levels of hepatic phase I and phase II enzymes, anti- oxidant enzymes, glutathione content and a decrease in lipid peroxidation. The skin papillomagenesis studies demonstrated a significant decrease (p<0.05 ) in the percentage of mice with papillomas, average number of papillomas per mouse and papillomas per papilloma bearing mouse when the animals received a topical application of the extract at a dose of 5mg/ kg body weight in the peri-initiation phase 7 days before and 7 days after DMBA application, Group II ), promotional phase (from the day of croton oil application and continued till the end of the experiment, Group III ) and both peri and post initiation stages (from 7 days prior to DMBA application and continued till the end of the experiment, Group IV) compared to the control group (Group I ). The percentage inhibition of tumor multiplicity has been recorded to be 27, 72, and 81 in Groups II, III, and IV, respectively. These findings are suggestive of a possible chemopreventive potential of Moringa oliefera drumstick extract against chemical carcinogenesis.